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2021 Audi A4
Premium Plus 3.0 TFSI quattro
vs
2026 Lexus IS
IS 350 F SPORT Design RWD

From $49,900 vs From $45,500

Audi A4
Audi A4
Premium Plus 3.0 TFSI quattro
From $49,900
★ Our Pick
View Full Specs →
VS
Lexus IS
Lexus IS
IS 350 F SPORT Design RWD
From $45,500
View Full Specs →
At a Glance
Power
349hp @ 6300
311hp @ 6600
Torque
369lb-ft @ 3200
280lb-ft @ 4800
Fuel
24 mpg est.
23 mpg est.
Engine
3.0 L/183ci
3.5 L/211ci

Choosing between the Audi A4 and the Lexus IS is one of the most common decisions car buyers in the United States face. The Audi A4 delivers 349hp @ 6300 while the Lexus IS produces 311hp @ 6600. On fuel, the A4 returns 24 mpg est. while the IS uses 23 mpg est. — important in a market where fuel prices change monthly. Pricing starts at $49,900 for the A4 and $45,500 for the IS. Both vehicles have their merits. The right choice depends on your priorities: fuel economy, performance, towing ability, safety features or total cost of ownership. This comparison covers every specification available so you can make an informed decision.

Specification
Audi A4Premium Plus 3.0 TFSI quattro 2021 - From $49,900
Lexus ISIS 350 F SPORT Design RWD 2026 - From $45,500
Performance
Power Output (hp)
349hp @ 6300
311hp @ 6600
Torque (lb-ft)
369lb-ft @ 3200
280lb-ft @ 4800
Engine & Drivetrain
Engine Capacity
3.0 L/183ci
3.5 L/211ci
Engine Layout
V
V
Cylinders
6
6
Fuel Type
Gasoline
Gasoline
Forced Induction Device
Turbocharged
—
Transmission
Automatic
Automatic w/OD
Number of Gears
8
8
Drive Wheels
All Wheel Drive
Rear Wheel Drive
Fuel Economy
Fuel Economy (Combined, est.)
24 mpg est.
23 mpg est.
Fuel Economy - City (mpg)
20 (2020)mpg
19 (Est)mpg
Fuel Economy - Highway (mpg)
28mpg
27 (Est)mpg
Fuel Tank Capacity (gal)
15.3gal
17.4gal
Dimensions
Length (in)
187.5in
185.4in
Width (in)
72.7in
72.4in
Height (in)
56.2in
56.5in
Wheelbase (in)
111in
110.2in
Curb Weight (lbs)
3847lbs
3913lbs
Safety
ABS
✓ Standard
✓ Standard
Brake Assist
✓ Standard
✓ Standard
Stability Control
✓ Standard
✓ Standard
Traction Control
✓ Standard
✓ Standard
Driver Airbag
✓ Standard
✓ Standard
Passenger Airbag
✓ Standard
✓ Standard
Side Airbags Front
✓ Standard
✓ Standard
Curtain Airbags
✓ Standard
✓ Standard
Features & Tech
Air Conditioning
✓ Standard
✓ Standard
Climate Control
✓ Standard
✓ Standard
Cruise Control
✓ Standard
✓ Standard
Adaptive Cruise Control
✓ Standard
✓ Standard
Bluetooth
✓ Standard
✓ Standard
Backup Camera
✓ Standard
✓ Standard
Rear Parking Aid
✓ Standard
✓ Standard
Sunroof
✓ Standard
✓ Standard
Heated Seats
✓ Standard
✓ Standard
Power Seat Adjustment
—
✓ Standard
Keyless Entry
✓ Standard
✓ Standard
Alloy Wheels
✓ Standard
✓ Standard

Which Wins?

Overall Winner
Audi A4
2 / 4 categories
Performance
A4
Fuel Economy
A4
Value
IS
Practicality
Tied
Audi A4
+Better fuel economy (24 mpg est.)
-Higher starting price
Lexus IS
+Lower starting price ($45,500)
-Higher fuel consumption (23 mpg est.)
Frequently Asked Questions
Which is more fuel efficient, the A4 or IS?
The A4 gets 24 mpg est. and the IS gets 23 mpg est. on the combined cycle. The A4 is the more fuel-efficient choice. In real-world conditions with a mix of highway and urban driving, actual figures will be slightly higher.
Which has more power, the A4 or IS?
The A4 produces 349hp @ 6300 and 369lb-ft @ 3200 of torque while the IS delivers 311hp @ 6600 and 280lb-ft @ 4800 of torque. The A4 is the more powerful option.
What is the price difference between the A4 and IS?
The A4 starts from $49,900 and the IS from $45,500. The IS is cheaper by $4,400 at this variant level. Final on-the-road pricing varies by dealer and specification.
Should I buy the A4 or the IS?
It depends on your priorities. If fuel economy matters most, check the mpg figures above. If you need towing capacity, compare the towing ratings. For day-to-day driving - commutes, school runs and highway trips - consider ground clearance, service network coverage, and total cost of ownership including insurance and maintenance. Use the spec tables above to compare every detail before making your decision.

Audi A4 Variants

All A4 Specs →

Lexus IS Variants

All IS Specs →

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